Prevalence of abdominal obesity among Chinese adults in 2011

Background

The prevalence of abdominal obesity is increasing dramatically worldwide. This study aimed to estimate the current prevalence of abdominal obesity from the 2011 China Health and Nutrition Survey (CHNS) and compare the data with other countries.

我国儿童青少年原发性高血压影响因素的Meta分析

目的评价我国儿童青少年原发性高血压的影响因素,为有效预防儿童高血压提供科学依据。方法在PubMed、CNKI、万方数据库中进行文献检索,收集2014年3月底之前公开发表的关于中国儿童原发性高血压影响因素的调查研究。采用RevMan 5.1和Stata11软件进行Meta分析,用固定效应模型或随机效应模型进行数据合并,计算OR值和95%CI。用Begg秩相关和漏斗图来判定发表偏倚。结果共纳入的23篇文献,包括113 315名调查儿童,影响因素合并的OR值分别为:肥胖4.63、超重2.46、家族史1.78、性别1.33、口味偏咸2.19、城镇1.86、运动0.59,均具有统计学意义。结论超重、肥胖、家族史、男性、口味偏咸、城镇是儿童高血压的危险因素,运动是儿童高血压的保护性因素。     

宣威地区肺癌患者血清和肺组织硒水平研究

背景与目的 宣威是我国肺癌高发区,有研究发现肿瘤的死亡率与硒的地理分布及摄入量呈负相关,肺癌死亡率与血硒水平呈负相关.本研究通过检测宣威肺癌患者的血清硒含量和肺组织硒水平.以初步探讨宣威地区肺癌高发与硒的关系.方法 取120例宣威女性的血清,其中试验组为60例肺癌患者,对照组为60例非肿瘤非呼吸道疾病人群,测定其血清硒...     

Estrogen Receptor α and β Expressions in Hypothalamus-pituitary-ovary Axis in Rats Exposed Lactationally to Soy Isoflavones and Bisphenol A

Objectives This paper aims to investigate the uterotrophic activities of lactational exposure to combination of soy isoflavones （SIF） and bisphenol A （BPA） and to examine estrogen receptor α （ERα） and estrogen receptor β （ERβ） expressions in hypothalamus-pituitary-ovary axis and uterus.Methods Maternal rats that were breeding about 8 litters were randomly divided into four groups with seven dams in each group.Dams in different treatment groups received corn oil （control）,150 mg/kg BW of SIF,150 mg/kg BW of BPA or combination of 150 mg/kg BW of SIF and 150 mg/kg BW of BPA,respectively,from postnatal day 5 to 11 （PND5-11） by gavage.On PND12 and PND70,10 female litters were killed and hypothalamus,pituitary,ovary and uterus were collected.ERα and ERβ expressions in these organs were detected with Western blotting assay.And vaginal opening time and estrus cycle were examined in animals fed for PND70.Results On PND12,the relative uterine weight of rats treated with ISF or BPA or their combination was significantly higher than that of untreated rats （P〈0.05）.But the relative uterine weight of rats in the co-exposure group was slightly lower than that in the group only exposed to SIF or BPA.On PND 70,however,the relative uterine weight in each treatment group was not statistically different from that in the control group （P〈0.05）.Vaginal opening time and estrus cycle in groups treated with SIF or BPA or their combination were similar to those in the control group （P〈0.05）.Exposure to SIF or BPA or their combination could up-regulate or down-regulate ERα and ERβ expressions in hypothalamus,pituitary,ovary and uterus on PND12 and PND70.These regulation patterns for ERα and ERβ were different in different organs at different time points.Conclusion Lactational exposure to ISF or BPA or their combination could induce uterotrophic responses in neonate rats,which disappeared in later life.But these data fail to suggest a possibility for synergic actions between SIF and BPA.It was also demonstrated that the uterotrophic effects of SIF and BPA exposure might,at least,involve modification of ERα or ERβ expressions in the hypothalamus-pituitary-ovary axis.